Потенциальные кандидаты
Jan. 31st, 2022 09:05 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisИндийцы в своих испытаниях показывают, что водный экстракт корней пелларгонии (Bi121, a standardized polyphenolic-rich compound isolated from Pelargonium sideodes), богатый полифенолами, может ингибировать заражение коронавирусом (разные штаммы) клеточных культур в пробирке.
Японцы же исследовали цетилпиридиниум хлорид, содержащийся в продуктах для гигиены в полости рта, и обнаружили, что в пробирке же, он ингибирует связывание шипика САРС2 с клеточным АСЕ2, после обработки культур 20-60 секунд.
Хорошо бы, чтоб и на животной моделив ещества показали себя надежными зщитниками..
We studied Bi121, a standardized polyphenolic-rich compound isolated from Pelargonium sideodes, against recombinant Vesicular Stomatitis Virus (rVSV)-pseudotyped SARS-CoV-2S (spike) that represent mutations in the spike protein of six different variants of SARS-CoV-2. Bi121 was effective in neutralizing all six rVSV-ΔG-SARS-CoV-2S variants expressing different mutations. The antiviral activity of Bi121 was then assessed against three variants of SARS-CoV-2 (USA WA1/2020, Hongkong/VM20001061/2020, B.1.167.2 (Delta)) using RT-qPCR and plaque assays in two different cell lines (Vero cells and HEK-ACE2). Bi121 showed significant activity toward all the three variants tested, suggesting a broad-spectrum activity.
This study examined the antiviral activity of CPC against SARS-CoV-2 and its inhibitory effect on the interaction between the viral spike (S) protein and ACE2 using an enzyme-linked immunosorbent assay. Results: CPC (0.05%, 0.1% and 0.3%) effectively inactivated SARS-CoV-2 within the contact times (20 and 60 s) in directions for use of oral care products in vitro. The binding ability of both the S protein and ACE2 were reduced by CPC. Conclusions: Our results suggest that CPC inhibits the interaction between S protein and ACE2, and thus, reduces infectivity of SARS-CoV-2 and suppresses viral adsorption.
Японцы же исследовали цетилпиридиниум хлорид, содержащийся в продуктах для гигиены в полости рта, и обнаружили, что в пробирке же, он ингибирует связывание шипика САРС2 с клеточным АСЕ2, после обработки культур 20-60 секунд.
Хорошо бы, чтоб и на животной моделив ещества показали себя надежными зщитниками..
We studied Bi121, a standardized polyphenolic-rich compound isolated from Pelargonium sideodes, against recombinant Vesicular Stomatitis Virus (rVSV)-pseudotyped SARS-CoV-2S (spike) that represent mutations in the spike protein of six different variants of SARS-CoV-2. Bi121 was effective in neutralizing all six rVSV-ΔG-SARS-CoV-2S variants expressing different mutations. The antiviral activity of Bi121 was then assessed against three variants of SARS-CoV-2 (USA WA1/2020, Hongkong/VM20001061/2020, B.1.167.2 (Delta)) using RT-qPCR and plaque assays in two different cell lines (Vero cells and HEK-ACE2). Bi121 showed significant activity toward all the three variants tested, suggesting a broad-spectrum activity.
This study examined the antiviral activity of CPC against SARS-CoV-2 and its inhibitory effect on the interaction between the viral spike (S) protein and ACE2 using an enzyme-linked immunosorbent assay. Results: CPC (0.05%, 0.1% and 0.3%) effectively inactivated SARS-CoV-2 within the contact times (20 and 60 s) in directions for use of oral care products in vitro. The binding ability of both the S protein and ACE2 were reduced by CPC. Conclusions: Our results suggest that CPC inhibits the interaction between S protein and ACE2, and thus, reduces infectivity of SARS-CoV-2 and suppresses viral adsorption.
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no subject
Date: 2022-02-01 01:48 pm (UTC)ты не бросайся тут научными названиями, ты пальцем, пальцем покажи что купить и чем полоскать!
no subject
Date: 2022-02-01 03:41 pm (UTC)no subject
Date: 2022-02-01 03:44 pm (UTC)но большинство исследований на эту тему не без греха- или в пробирке или наблюдательные, те умеренно доказательные.