От штамма- зависит
Jun. 25th, 2022 09:03 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisИсследование на выборке больных умеренных ковидом, в Бразилии, показало, что штамм тоже вносит определенный вклад в то, теряет ли заболевший нюх или нет.
Когда в популяции ходил "уханьский" штамм, обоняние пропадало или изменялось у 53% болеющих ковидом "умеренно". Для "гаммы" этот показатель был 28%, для "дельты"- 42%, для "омикрона"- всего 6%.
Характерно, что это снижение влияния на нюх не было вызвано тем, что заболевшие были вакцинированы и имели иммунитет, а обсуловлено особенностями штамма.
Olfactory dysfunction is a common symptom of COVID-19, with reported rates as high as 70%. This symptom can be associated with mild COVID-19, mostly occurs within 5 days after symptom onset, and can persist for a few days to several months after infection resolution.1 The mechanism of SARS-CoV-2–related olfactory dysfunction is not completely understood
Host genetics,2 acute inflammation in the olfactory epithelium,3 local ACE2 expression,4 and downregulation of olfactory receptors5 seem to play a role; however, the viral contribution remains to be explored. We conducted a retrospective analysis of individuals with mild COVID-19 during different SARS-CoV-2 variant waves to assess the prevalence of self-reported olfactory dysfunction.
Of the 6053 participants with mild COVID-19 in the cohort, 2650 reported olfactory dysfunction (Table 1) and 3403 did not report this symptom. Olfactory dysfunction was reported by 2223 of the 4227 participants (52.6% [95% CI, 51.1%-54.1%]) diagnosed during the period of the original lineages (Table 2). The prevalence decreased to 27.5% (95% CI, 24.3%-30.8%) during Gamma, 42.1% (95% CI, 37.4%-47.0%) during Delta, and 5.8% (95% CI, 4.4%-8.5%) during Omicron.
This study found that individuals with mild COVID-19 infected during the Gamma and Omicron waves had lower odds of reporting olfactory dysfunction than individuals infected during the period of the original lineages. These results suggest that the type of SARS-CoV-2 variant might be a risk factor for olfactory dysfunction, along with host genetic susceptibility.2 The association with Omicron also was observed after controlling for vaccination status, supporting its independence of host immunologic factors.
Когда в популяции ходил "уханьский" штамм, обоняние пропадало или изменялось у 53% болеющих ковидом "умеренно". Для "гаммы" этот показатель был 28%, для "дельты"- 42%, для "омикрона"- всего 6%.
Характерно, что это снижение влияния на нюх не было вызвано тем, что заболевшие были вакцинированы и имели иммунитет, а обсуловлено особенностями штамма.
Olfactory dysfunction is a common symptom of COVID-19, with reported rates as high as 70%. This symptom can be associated with mild COVID-19, mostly occurs within 5 days after symptom onset, and can persist for a few days to several months after infection resolution.1 The mechanism of SARS-CoV-2–related olfactory dysfunction is not completely understood
Host genetics,2 acute inflammation in the olfactory epithelium,3 local ACE2 expression,4 and downregulation of olfactory receptors5 seem to play a role; however, the viral contribution remains to be explored. We conducted a retrospective analysis of individuals with mild COVID-19 during different SARS-CoV-2 variant waves to assess the prevalence of self-reported olfactory dysfunction.
Of the 6053 participants with mild COVID-19 in the cohort, 2650 reported olfactory dysfunction (Table 1) and 3403 did not report this symptom. Olfactory dysfunction was reported by 2223 of the 4227 participants (52.6% [95% CI, 51.1%-54.1%]) diagnosed during the period of the original lineages (Table 2). The prevalence decreased to 27.5% (95% CI, 24.3%-30.8%) during Gamma, 42.1% (95% CI, 37.4%-47.0%) during Delta, and 5.8% (95% CI, 4.4%-8.5%) during Omicron.
This study found that individuals with mild COVID-19 infected during the Gamma and Omicron waves had lower odds of reporting olfactory dysfunction than individuals infected during the period of the original lineages. These results suggest that the type of SARS-CoV-2 variant might be a risk factor for olfactory dysfunction, along with host genetic susceptibility.2 The association with Omicron also was observed after controlling for vaccination status, supporting its independence of host immunologic factors.
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no subject
Date: 2022-06-26 05:22 am (UTC)no subject
Date: 2022-06-26 05:49 am (UTC)no subject
Date: 2022-06-26 10:01 pm (UTC)no subject
Date: 2022-06-27 05:49 am (UTC)пока что видно что омикроны протекают лечге в общем и целом, надеюсь нет ничего скрытого.