Время суток и прививка
Oct. 29th, 2021 11:48 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisРабота по данным титров антител (и пр) около 3 тыс английских медработников, где показано на примере мРНК (файзер) и векторной вакцин (астра-зенека), что иммунитет вырабатывается лучше (для обоих типов вакцин), если прививку делать ближе к вечеру (15-21 час). Спустя 2 недели после прививки отличия особенно ярко выражены, спустя 6 недель, отличия почти стираются.
Другой "более подходящий" период был с 7 до 11 утра. Слабее всего- между этими 2мя периодами времени.
Касательно типов вакцин- мРНК вызывала стабильно более сильный иммунный ответ, и титры были выше для всех периодов времени (и суток, и взятия проб крови для теста после прививки) и для всех возрастов.
Ожидаемо, титры антител были выше у более молодых (16-29 лет) и ниже всего у пожилых (50-74).
У женщин были титры выше, чем у мужчин.
The circadian clock is an endogenous 24 hour clock that regulates many aspects of physiology, including the response to infectious disease and vaccination (Allada and Bass, 2021). A recent report demonstrated significant daytime variation in multiple immune parameters in >300,000 participants in the UK Biobank, highlighting the diurnal nature of innate and adaptive immune responses (Wyse et al., 2021). Human lung diseases frequently show time-of-day variation in symptom severity and respiratory function and the circadian transcriptional activator BMAL1 has been shown to regulate respiratory inflammation (Ehlers et al., 2018; Ince et al., 2019). Influenza A virus infection of circadian-arrhythmic mice is associated with elevated inflammatory responses and a higher viral burden (Edgar et al., 2016; Sengupta et al., 2019). The time-of-day of influenza vaccination in elderly men affected antibody responses with higher titres noted in the morning (Phillips et al., 2008; Long et al., 2016). An additional influenza vaccination study reported that the time of sample collection rather than vaccination had a more significant effect on antibody responses Kurupati et al., 2017). We and others have proposed a role for circadian signalling in regulating SARS-CoV-2 host immune responses and COVID-19 severity (Ray and Reddy, 2020; Maidstone et al., 2021; Sengupta et al., 2021). Clearly, it is important to assess whether the time of SARS-CoV-2 vaccination impacts host antibody responses. Data from 2784 participants (Table 1A) were analyzed using linear mixed modelling to investigate the effects of time of vaccination on anti-Spike antibody levels. Variation between participants was modelled with fixed factors of time-of-day of vaccination (Time 1, 07:00-10:59; Time 2, 11:00-14:59; Time 3, 15:00-21:59) accine type (Pfizer, mRNA bnt162b2 or AstraZeneca, Adenoviral AZD1222), age group (16-29, 30-39, 40-49 or 50-74 years), sex, and the number of days post-vaccination. his analysis allowed us to estimate the average anti-Spike levels in each participant group at 2 and 6 weeks post-vaccination Using a linear mixed-model approach, we found that anti-Spike responses were higher in those who were vaccinated later in the day (p=0.013), in those who received the Pfizer mRNA vaccine (p<0.0001), in women (p=0.013) and in younger participants (p<0.0001) Our analysis of 2784 healthcare workers reveals a significant effect of the time of vaccination on anti-Spike antibody levels following the administration of two alternative SARS-CoV-2 vaccines (mRNA or Adenovirus based). A recent report studying a small cohort of healthcare workers immunised with an inactivated SARS-CoV-2 vaccine in the morning (09:00 -11:00,n=33) or afternoon (15:00 -17:00, n=30) showed increased B-cell responses and anti-Spike antibodies in participants vaccinated in the morning (Zhang et al., 2021). This contrasts with our observations and may reflect the use of an inactivated whole virus immunogen that will likely induce polytypic responses to a range of SARS-CoV-2 encoded proteins. Our observation contrasts with earlier studies in elderly men that reported higher anti-influenza titers in the morning (Phillips et al., 2008; Long et al., 2016). This may reflect differences between the cohorts studied, particularly with regard to immune status; we studied seronegative participants whereas responses to influenza vaccination will involve the stimulation of memory responses. Sample collection time in this study showed no significant association with anti-Spike levels, in contrast to previous reports (Kurupati et al., 2017; McNaughton et al., 2021). These data highlight the importance of recording the time of vaccination in clinical and research studies, and highlight the importance of considering time-of-day factors in future study designs that may reduce inter-individual variance and the number of participants needed to obtain statistical significance. It is worth noting that, despite the significant differences in anti-Spike levels detected in participants receiving Pfizer mRNA or AstraZeneca Adenoviral vaccines, both show comparable efficacies highlighting the robust nature of the host antibody response.
Другой "более подходящий" период был с 7 до 11 утра. Слабее всего- между этими 2мя периодами времени.
Касательно типов вакцин- мРНК вызывала стабильно более сильный иммунный ответ, и титры были выше для всех периодов времени (и суток, и взятия проб крови для теста после прививки) и для всех возрастов.
Ожидаемо, титры антител были выше у более молодых (16-29 лет) и ниже всего у пожилых (50-74).
У женщин были титры выше, чем у мужчин.
The circadian clock is an endogenous 24 hour clock that regulates many aspects of physiology, including the response to infectious disease and vaccination (Allada and Bass, 2021). A recent report demonstrated significant daytime variation in multiple immune parameters in >300,000 participants in the UK Biobank, highlighting the diurnal nature of innate and adaptive immune responses (Wyse et al., 2021). Human lung diseases frequently show time-of-day variation in symptom severity and respiratory function and the circadian transcriptional activator BMAL1 has been shown to regulate respiratory inflammation (Ehlers et al., 2018; Ince et al., 2019). Influenza A virus infection of circadian-arrhythmic mice is associated with elevated inflammatory responses and a higher viral burden (Edgar et al., 2016; Sengupta et al., 2019). The time-of-day of influenza vaccination in elderly men affected antibody responses with higher titres noted in the morning (Phillips et al., 2008; Long et al., 2016). An additional influenza vaccination study reported that the time of sample collection rather than vaccination had a more significant effect on antibody responses Kurupati et al., 2017). We and others have proposed a role for circadian signalling in regulating SARS-CoV-2 host immune responses and COVID-19 severity (Ray and Reddy, 2020; Maidstone et al., 2021; Sengupta et al., 2021). Clearly, it is important to assess whether the time of SARS-CoV-2 vaccination impacts host antibody responses. Data from 2784 participants (Table 1A) were analyzed using linear mixed modelling to investigate the effects of time of vaccination on anti-Spike antibody levels. Variation between participants was modelled with fixed factors of time-of-day of vaccination (Time 1, 07:00-10:59; Time 2, 11:00-14:59; Time 3, 15:00-21:59) accine type (Pfizer, mRNA bnt162b2 or AstraZeneca, Adenoviral AZD1222), age group (16-29, 30-39, 40-49 or 50-74 years), sex, and the number of days post-vaccination. his analysis allowed us to estimate the average anti-Spike levels in each participant group at 2 and 6 weeks post-vaccination Using a linear mixed-model approach, we found that anti-Spike responses were higher in those who were vaccinated later in the day (p=0.013), in those who received the Pfizer mRNA vaccine (p<0.0001), in women (p=0.013) and in younger participants (p<0.0001) Our analysis of 2784 healthcare workers reveals a significant effect of the time of vaccination on anti-Spike antibody levels following the administration of two alternative SARS-CoV-2 vaccines (mRNA or Adenovirus based). A recent report studying a small cohort of healthcare workers immunised with an inactivated SARS-CoV-2 vaccine in the morning (09:00 -11:00,n=33) or afternoon (15:00 -17:00, n=30) showed increased B-cell responses and anti-Spike antibodies in participants vaccinated in the morning (Zhang et al., 2021). This contrasts with our observations and may reflect the use of an inactivated whole virus immunogen that will likely induce polytypic responses to a range of SARS-CoV-2 encoded proteins. Our observation contrasts with earlier studies in elderly men that reported higher anti-influenza titers in the morning (Phillips et al., 2008; Long et al., 2016). This may reflect differences between the cohorts studied, particularly with regard to immune status; we studied seronegative participants whereas responses to influenza vaccination will involve the stimulation of memory responses. Sample collection time in this study showed no significant association with anti-Spike levels, in contrast to previous reports (Kurupati et al., 2017; McNaughton et al., 2021). These data highlight the importance of recording the time of vaccination in clinical and research studies, and highlight the importance of considering time-of-day factors in future study designs that may reduce inter-individual variance and the number of participants needed to obtain statistical significance. It is worth noting that, despite the significant differences in anti-Spike levels detected in participants receiving Pfizer mRNA or AstraZeneca Adenoviral vaccines, both show comparable efficacies highlighting the robust nature of the host antibody response.
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Date: 2021-10-30 06:32 pm (UTC)no subject
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Date: 2021-10-31 03:49 am (UTC)no subject
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Date: 2021-10-31 05:37 am (UTC)"... и ниже всего у пожилых (50-74)", а мы с мужем уже старше74-х и чо:))
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Date: 2021-10-31 04:50 pm (UTC)