Генетические вариации
Dec. 2nd, 2020 09:12 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisГены у всех слегка отличаются. Как оказалось, у тех, кто болеет ковидом тяжело- есть некоторые общие генетические особенности, которые делают клетки их иммунной системы более уязвимыми к воздействию коронавируса.
Среди найденных отличий авторы исследования придают значение генам, усиливающих продукцию хемокиновых и цитокиновых рецепторов на поверхности ядерных клеток крови- моноцитов и Т-лимфоцитов разных типов.
Не менее важно и то, что у многих из группы тяжелых ковидных был генотип, при котором может вырабатываться мало интерферона и больше интерлейкина 10, а Т и В лимфоциты могут быть с легка "вялыми" из-за особенностей генома.
COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.
The expression of 11protein-coding genesand 1non-coding RNA(referred here aseGenes) wasassociated with the genetic variants linked to severe COVID-19 illness requiring hospitalization. Notably, the majorityof the eGenes associated with severe COVID-19 illness showed prominent effects in specific immune cell types... we identified 41additionaleGenesthat were associated with genetic variantsnon-significantly linked to severe COVID-19 illness
Populations with higherfrequency of this Neanderthal-origin COVID-19-risk haplotypehave higher risk of severe COVID-19 illness
The expression of several genes showed prominent genotype-dependent effects in non-classical monocytes, NK cells, B cells, or specific T cell subtypes, highlighting the potential of COVID-19 genetic risk variants to impact the function of diverse immune cell types and influence severe disease manifestations.
In summary, several severe COVID-19-risk variants show cell-type-restriction of their effects on gene expression, and thus have the potentialtoimpact the function of diverse immune cell types and gene pathways. Our analysis of eQTLs and cis-interaction maps in multiple immune cell types enabled a precise definition of the cell types and genes that drivegenetic susceptibility to severe COVID-19 illness, potentially contributing to the different clinical outcomes. Our study also highlights how information about common genetic polymorphisms can be used to define molecular pathways and cell types that play a role in disease pathogenesis.
Среди найденных отличий авторы исследования придают значение генам, усиливающих продукцию хемокиновых и цитокиновых рецепторов на поверхности ядерных клеток крови- моноцитов и Т-лимфоцитов разных типов.
Не менее важно и то, что у многих из группы тяжелых ковидных был генотип, при котором может вырабатываться мало интерферона и больше интерлейкина 10, а Т и В лимфоциты могут быть с легка "вялыми" из-за особенностей генома.
COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.
The expression of 11protein-coding genesand 1non-coding RNA(referred here aseGenes) wasassociated with the genetic variants linked to severe COVID-19 illness requiring hospitalization. Notably, the majorityof the eGenes associated with severe COVID-19 illness showed prominent effects in specific immune cell types... we identified 41additionaleGenesthat were associated with genetic variantsnon-significantly linked to severe COVID-19 illness
Populations with higherfrequency of this Neanderthal-origin COVID-19-risk haplotypehave higher risk of severe COVID-19 illness
The expression of several genes showed prominent genotype-dependent effects in non-classical monocytes, NK cells, B cells, or specific T cell subtypes, highlighting the potential of COVID-19 genetic risk variants to impact the function of diverse immune cell types and influence severe disease manifestations.
In summary, several severe COVID-19-risk variants show cell-type-restriction of their effects on gene expression, and thus have the potentialtoimpact the function of diverse immune cell types and gene pathways. Our analysis of eQTLs and cis-interaction maps in multiple immune cell types enabled a precise definition of the cell types and genes that drivegenetic susceptibility to severe COVID-19 illness, potentially contributing to the different clinical outcomes. Our study also highlights how information about common genetic polymorphisms can be used to define molecular pathways and cell types that play a role in disease pathogenesis.
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Date: 2020-12-03 06:25 pm (UTC)no subject
Date: 2020-12-03 07:50 pm (UTC)глядишь, со временем (лет дцать)- и более серьезно станут относится к индивидуальным особенностям больных- а не ориентирвоаться на среднюю температуру по больнице в показателях.