Похудение не равно здоровье?
Jan. 23rd, 2024 08:05 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisВышла статья, в которой определили, на базе данных примерно 160 тыс медработников старше 40 лет (начиная с 1978 года по 2016), что если человек после 40 сбросил около 10% веса за год-два, то его шансы заболеть любым раком, начиная с примерно с полгода-год спустя после похудания, прилично возросли ( в полтора раза) по сравнению с теми, кто не худел.
The cancer incidence rate was 1362 cases/100 000 person-years among participants with recent weight loss of greater than 10.0% vs 869 cases/100 000 person-years among those without recent weight loss (between-group difference, 493 cases/100 000 person-years [95% CI, 391-594 cases/100 000 person-years], P < .001. При этом, weight loss prior to cancer diagnosis was not associated with a more advanced cancer stage at presentation.
Для некоторых видов рака разница в 2-5 раза.
Cancer of the upper gastrointestinal tract (esophagus, stomach, liver, biliary tract, or pancreas) was particularly common among participants with recent weight loss; there were 173 cases/100 000 person-years for those with weight loss of greater than 10.0% of body weight compared with 36 cases/100 000 person-years for those without recent weight loss .. For hematological types of cancer (non-Hodgkin lymphoma, multiple myeloma, and leukemia), there were 146 cases/100 000 person-years for those with weight loss of greater than 10.0% vs 66 cases/100 000 person-years for those without recent weight loss... For colorectal cancer, there were 141 cases/100 000 person-years for those with weight loss of greater than 10.0% vs 77 cases/100 000 person-years for those without recent weight loss. For lung cancer, there were 177 cases/100 000 person-years for those with weight loss of greater than 10.0% vs 72 cases/100 000 person-years for those without recent weight loss (eTable 4 in Supplement 1). For these cancer types, higher incidence rates were identified as the magnitude of weight loss increased (eFigure 3 in Supplement 1). In contrast, no statistically significant associations were identified between recent weight loss and cancer of the breast, genital system, urinary system, brain, or melanoma. Compared with participants without recent weight loss, recent and greater total weight loss was significantly associated with higher 1-year relative risk of total cancer, upper gastrointestinal tract cancer, hematological cancer, colorectal cancer, and lung cancer.
Risk of cancer diagnosis (total cancer, upper gastrointestinal tract cancer, hematological cancer, colorectal cancer, or lung cancer) was higher during the first 12 months compared with during the 13 to 24 months after reporting weight loss.
Так что, если человек "в возрасте" худеет (просто так, без прикладывания усилий, не изза целенаправленных действий вроде низкокалорийной диеты и упражнений (хотя там тоже слегка повысилось) -то это признак проблем со здоровьем. Статистика подтверждает эмпирические наблюдения.
The cancer incidence rate was 1362 cases/100 000 person-years among participants with recent weight loss of greater than 10.0% vs 869 cases/100 000 person-years among those without recent weight loss (between-group difference, 493 cases/100 000 person-years [95% CI, 391-594 cases/100 000 person-years], P < .001. При этом, weight loss prior to cancer diagnosis was not associated with a more advanced cancer stage at presentation.
Для некоторых видов рака разница в 2-5 раза.
Cancer of the upper gastrointestinal tract (esophagus, stomach, liver, biliary tract, or pancreas) was particularly common among participants with recent weight loss; there were 173 cases/100 000 person-years for those with weight loss of greater than 10.0% of body weight compared with 36 cases/100 000 person-years for those without recent weight loss .. For hematological types of cancer (non-Hodgkin lymphoma, multiple myeloma, and leukemia), there were 146 cases/100 000 person-years for those with weight loss of greater than 10.0% vs 66 cases/100 000 person-years for those without recent weight loss... For colorectal cancer, there were 141 cases/100 000 person-years for those with weight loss of greater than 10.0% vs 77 cases/100 000 person-years for those without recent weight loss. For lung cancer, there were 177 cases/100 000 person-years for those with weight loss of greater than 10.0% vs 72 cases/100 000 person-years for those without recent weight loss (eTable 4 in Supplement 1). For these cancer types, higher incidence rates were identified as the magnitude of weight loss increased (eFigure 3 in Supplement 1). In contrast, no statistically significant associations were identified between recent weight loss and cancer of the breast, genital system, urinary system, brain, or melanoma. Compared with participants without recent weight loss, recent and greater total weight loss was significantly associated with higher 1-year relative risk of total cancer, upper gastrointestinal tract cancer, hematological cancer, colorectal cancer, and lung cancer.
Risk of cancer diagnosis (total cancer, upper gastrointestinal tract cancer, hematological cancer, colorectal cancer, or lung cancer) was higher during the first 12 months compared with during the 13 to 24 months after reporting weight loss.
Так что, если человек "в возрасте" худеет (просто так, без прикладывания усилий, не изза целенаправленных действий вроде низкокалорийной диеты и упражнений (хотя там тоже слегка повысилось) -то это признак проблем со здоровьем. Статистика подтверждает эмпирические наблюдения.
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