Заразность омикрона
Jan. 14th, 2022 12:01 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisДанные по Швеции, когда исследователи сравнивают состояние иммунного ответа при инфекции омикроном или дельтой при пробоях. Вкратце- у привитых иммунитет хорошо реагирует, и на дельту, и на омикрон, хоть и со своими, отличными друг от друга, тонкостями-особенностями. При омикроновой инфекции помогает клеточный иммунитет, который прививкой "проинициирован". Все у них болели легко-умеренно, как ОРЗ. В публикации много всяких деталей по состоянию клеточного иммунитета после стимуляции этими штаммами, но я тут об этой работе в контексте чего ожидать привитому при встрече с омикроном.
Омикроновая группа пробоев- после новогодней вечеринки. Все были молодые, и привитые (3-6 месяцев после прививки мРНК вакцинами), изаразилось-заболело 74%.
На мой взгляд, показательно про то, на сколько заразен омикрон для привитых в реальных условиях.
It is unclear how vaccine immunity protects against Omicron infection. Here we show that vaccinated participants at a superspreader event had robust recall response of humoral and pre-existing cellular immunity induced by the vaccines, and an emergent de novo T cell response to non-Spike antigens. We compared cases from a Christmas party where 81 of 110 (74%) developed Omicron breakthrough COVID-19, with Delta breakthrough cases and vaccinated non-infected controls. Omicron cases had significantly increased activated SARS-CoV-2 wild type Spike-specific (vaccine) cytotoxic T cells, activated follicular helper (TFH) cells, functional T cell responses, boosted humoral responses, activated anti-Spike plasmablasts and anti-RBD memory B cells compared to controls. Omicron cases had significantly increased de novo memory T cell responses to non-Spike viral antigens compared to Delta breakthrough cases demonstrating development of broad immunity. The rapid release of Spike and RBD-specific IgG+ B cell plasmablasts and memory B cells into circulation suggested affinity maturation of antibodies and that concerted T and B cell immunity may provide durable broad immunity.
Омикроновая группа пробоев- после новогодней вечеринки. Все были молодые, и привитые (3-6 месяцев после прививки мРНК вакцинами), изаразилось-заболело 74%.
На мой взгляд, показательно про то, на сколько заразен омикрон для привитых в реальных условиях.
It is unclear how vaccine immunity protects against Omicron infection. Here we show that vaccinated participants at a superspreader event had robust recall response of humoral and pre-existing cellular immunity induced by the vaccines, and an emergent de novo T cell response to non-Spike antigens. We compared cases from a Christmas party where 81 of 110 (74%) developed Omicron breakthrough COVID-19, with Delta breakthrough cases and vaccinated non-infected controls. Omicron cases had significantly increased activated SARS-CoV-2 wild type Spike-specific (vaccine) cytotoxic T cells, activated follicular helper (TFH) cells, functional T cell responses, boosted humoral responses, activated anti-Spike plasmablasts and anti-RBD memory B cells compared to controls. Omicron cases had significantly increased de novo memory T cell responses to non-Spike viral antigens compared to Delta breakthrough cases demonstrating development of broad immunity. The rapid release of Spike and RBD-specific IgG+ B cell plasmablasts and memory B cells into circulation suggested affinity maturation of antibodies and that concerted T and B cell immunity may provide durable broad immunity.
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