Женщинам на заметку
Oct. 12th, 2021 11:34 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisЖенщинами оттмечались случаи преждевременных, неожиданных, более длинных или тяжелых кровотечений после прививок от ковида.
И вот есть уже и цифровые данные, кроме наблюдений озабоченных происходящим участниц.
Данные собраны в США примерно по 40 тыс привитым от 18 до 80 лет.
Среди женщин с нормальным циклом, у 42% месячные кровотечения были более обильными, у 34% более долгими, после прививки. У 44% не наблюдалось никаких изменений в цикле. У тех, у кого цикл не регулярный- 40% отметили более обильные кровотечения после прививки, и 43%- более длительные. Для тех кто в пре-менопаузе, это было 42% и 43%, соответсвенно.
Среди тех, кто на гормонах (либо предотвращение беременности, либо по смене пола) или в менопаузе(не более нескольких лет) случаи неожиданных кровотечений были чаще: 71%, 39% и 66%, соответственно.
Зачастую, кровотечения были у тех у кого наблюдались и другие общие реакции на прививку от ковида (вроде температуры, слабости, итп). Так же, есть ассоциации с возрастом, предыдущими беременностями и этнической принадлежностью.
Да, среди ответивших женщин, "общие реакции" на прививку отмечались у 54% выборки на первую дозу, и 75% на вторую.
Ассоциаций с типом вакцины не обнаружено. Но проблем с кровотечениями после прививки было больше среди тех женщины, у которых были диагнозы "по женски" (эндометриоз, фиброид, меноррагия), чем у "недиагностированных".
Menstruating and formerly menstruating people began sharing that they experienced unexpected bleeding after being administered a SARS-CoV-2 vaccine in early 2021. Vaccine trial protocols do not typically monitor for major adverse events for more than seven days, and additional follow up communications do not inquire about menstrual cycles or bleeding. Therefore, manufacturers had no way of addressing the extent to which this observation was a coincidence or a potential side effect of the vaccines. In mainstream media coverage, medical doctors and public health experts hastened to say that there was “no biological mechanism” or “no data” to support a relationship between vaccine administration and menstrual changes. In other cases experts declared that these changes were more likely a result of “stress”(1–4). Unfortunately, dismissal by medical experts fueled greater concerns, as both vaccine 59hesitant and anti-vaccine individuals and organizations began to conflate the possibility of short-60term menstrual changes with long-term harms to fertility. Pundits, politicians, religious leaders, and wellness influencers worked the oft-used framing of protecting women to advise against the vaccine(5–9).As the SARS-CoV-2 vaccine became available to adolescents, calls to understand the menstrual changes associated with the vaccine increased as parents felt they were weighing their child’s pubertal development and future fertility against their risk of getting COVID-19 Vaccines function by mobilizing the immune system to protect from disease if exposure occurs. This immune activation is important, although it may also produce a cascade of other localized (e.g., soreness at injection site) or systemic (e.g., fatigue, fever) inflammatory responses. Studies that assess the direct effect of vaccination on the menstrual cycle are few and far between. A study from 1913 identified that the typhoid vaccine was associated with menstrual irregularities, which included missed, late, and early menstruation, discomfort, and heavy 88bleeding in more than half of their female sample(33).Hepatitis B studies have also indicated 89that menstruation could be altered(34),and a HPV post-market safety study found that over a 90quarter of participants reported menstrual irregularity(35). The speed and coverage of the current COVID-19 pandemic vaccination campaign may have inadvertently highlighted a previously under-recognized side effect of especially immunogenic vaccines administered in adulthood, which is that systemic inflammatory responses may in some individuals invoke downstream responses in target organs such as the uterus.
Many people began sharing that they experienced unexpected menstrual bleeding after SARS-CoV-2 inoculation. This emerging phenomenon was undeniable yet understudied. We investigated menstrual bleeding patterns among currently and formerly menstruating people, with a research design based off our expectations that these bleeding changes related to changes in clotting or inflammation, affecting normal menstrual repair. In this sample, 42% of people with regular menstrual cycles bled more heavily than usual, while 44% reported no change, after being vaccinated. Among people who typically do not menstruate, 71% of people on long-acting reversible contraceptives, 39% of people on gender-affirming hormones, and 66% of post-menopausal people reported breakthrough bleeding. We found increased/breakthrough bleeding was significantly associated with age, other vaccine side effects (fever, fatigue), history of pregnancy or birth, and ethnicity. Changes to menstrual bleeding are not uncommon nor dangerous, yet attention to these experiences is necessary to build trust in medicine.
И вот есть уже и цифровые данные, кроме наблюдений озабоченных происходящим участниц.
Данные собраны в США примерно по 40 тыс привитым от 18 до 80 лет.
Среди женщин с нормальным циклом, у 42% месячные кровотечения были более обильными, у 34% более долгими, после прививки. У 44% не наблюдалось никаких изменений в цикле. У тех, у кого цикл не регулярный- 40% отметили более обильные кровотечения после прививки, и 43%- более длительные. Для тех кто в пре-менопаузе, это было 42% и 43%, соответсвенно.
Среди тех, кто на гормонах (либо предотвращение беременности, либо по смене пола) или в менопаузе(не более нескольких лет) случаи неожиданных кровотечений были чаще: 71%, 39% и 66%, соответственно.
Зачастую, кровотечения были у тех у кого наблюдались и другие общие реакции на прививку от ковида (вроде температуры, слабости, итп). Так же, есть ассоциации с возрастом, предыдущими беременностями и этнической принадлежностью.
Да, среди ответивших женщин, "общие реакции" на прививку отмечались у 54% выборки на первую дозу, и 75% на вторую.
Ассоциаций с типом вакцины не обнаружено. Но проблем с кровотечениями после прививки было больше среди тех женщины, у которых были диагнозы "по женски" (эндометриоз, фиброид, меноррагия), чем у "недиагностированных".
Menstruating and formerly menstruating people began sharing that they experienced unexpected bleeding after being administered a SARS-CoV-2 vaccine in early 2021. Vaccine trial protocols do not typically monitor for major adverse events for more than seven days, and additional follow up communications do not inquire about menstrual cycles or bleeding. Therefore, manufacturers had no way of addressing the extent to which this observation was a coincidence or a potential side effect of the vaccines. In mainstream media coverage, medical doctors and public health experts hastened to say that there was “no biological mechanism” or “no data” to support a relationship between vaccine administration and menstrual changes. In other cases experts declared that these changes were more likely a result of “stress”(1–4). Unfortunately, dismissal by medical experts fueled greater concerns, as both vaccine 59hesitant and anti-vaccine individuals and organizations began to conflate the possibility of short-60term menstrual changes with long-term harms to fertility. Pundits, politicians, religious leaders, and wellness influencers worked the oft-used framing of protecting women to advise against the vaccine(5–9).As the SARS-CoV-2 vaccine became available to adolescents, calls to understand the menstrual changes associated with the vaccine increased as parents felt they were weighing their child’s pubertal development and future fertility against their risk of getting COVID-19 Vaccines function by mobilizing the immune system to protect from disease if exposure occurs. This immune activation is important, although it may also produce a cascade of other localized (e.g., soreness at injection site) or systemic (e.g., fatigue, fever) inflammatory responses. Studies that assess the direct effect of vaccination on the menstrual cycle are few and far between. A study from 1913 identified that the typhoid vaccine was associated with menstrual irregularities, which included missed, late, and early menstruation, discomfort, and heavy 88bleeding in more than half of their female sample(33).Hepatitis B studies have also indicated 89that menstruation could be altered(34),and a HPV post-market safety study found that over a 90quarter of participants reported menstrual irregularity(35). The speed and coverage of the current COVID-19 pandemic vaccination campaign may have inadvertently highlighted a previously under-recognized side effect of especially immunogenic vaccines administered in adulthood, which is that systemic inflammatory responses may in some individuals invoke downstream responses in target organs such as the uterus.
Many people began sharing that they experienced unexpected menstrual bleeding after SARS-CoV-2 inoculation. This emerging phenomenon was undeniable yet understudied. We investigated menstrual bleeding patterns among currently and formerly menstruating people, with a research design based off our expectations that these bleeding changes related to changes in clotting or inflammation, affecting normal menstrual repair. In this sample, 42% of people with regular menstrual cycles bled more heavily than usual, while 44% reported no change, after being vaccinated. Among people who typically do not menstruate, 71% of people on long-acting reversible contraceptives, 39% of people on gender-affirming hormones, and 66% of post-menopausal people reported breakthrough bleeding. We found increased/breakthrough bleeding was significantly associated with age, other vaccine side effects (fever, fatigue), history of pregnancy or birth, and ethnicity. Changes to menstrual bleeding are not uncommon nor dangerous, yet attention to these experiences is necessary to build trust in medicine.
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