Нарушения работы сердца после прививки
Aug. 10th, 2021 08:55 pm![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
chuka_lisВышла статья, в которой проведен анализ по рапортам случаев осложнений сердечно-сосудистого спектра после прививки от ковида. Они есть, и многие из них - серьезные.
Добавлю- далеко не все случаи попали в эти отчеты.
Те данные, что в статье- это только за месяц с начала прививок.
This study included all the adverse events notified concerning all the suspected cardiovascular adverse events reported in VigiBase after administering any of the three COVID-19 vaccines: BNT162b2 Pfizer, 1222 AstraZeneca, and Moderna between December 15, 2020, and January 24, 2021.
There were 103,954 adverse events reported for 30,523 patients from 15th December 2020 to 24th January 2021 (Figure 1). Most of the adverse events (AEs) were reported for three vaccines: BNT162b2 Pfizer, 1222 AstraZeneca, and Moderna COVID-19 vaccines since during the study period, these vaccines were used more commonly. Only one AE was reported from the AG0301-COVID19 vaccine and 32 from SARS-CoV-2 Vaccine (Vero Cell) Inactivated vaccine; none of these AEs were related to the cardiovascular system. A total of 4863 cardiovascular adverse events were reported from the COVID-19 vaccines.
Common adverse events observed with vaccines under study were tachycardia (16.41%), flushing (12.17%). Hypertension (5.82%), hypotension (3.60%) and peripheral coldness (2.41%).
According to the disproportionality analysis based on IC025 values, acute myocardial infarction, cardiac arrest, and circulatory collapse were associated with the vaccine used in the age group > 75 years. Hypertension and severe hypertension like hypertensive emergency and urgency were associated with vaccine use in almost all age groups and genders. Vaccines were also associated with rhythm disorders such as supraventricular tachycardia, sinus tachycardia, paroxysmal tachycardia, palpitations, etc. Peripheral circular failure was also found to be associated with vaccine use. Amongst the investigations and lab tests, abnormal ECG findings, raised C-reactive protein, increase in D-dimer, increase in troponin was found to be associated with the vaccine used in specific age group or gender or all subjects (Table 3).
We explored the global pharmacovigilance database VigiBase for cardiovascular adverse events reported for COVID-19 vaccines in the present study. The majority of the present study’s adverse events were BNT162b2 Pfizer, 1222 AstraZeneca, and Moderna vaccines. The elderly age group was associated with acute myocardial infarction, cardiac arrest, and circulatory collapse. Hypertension, severe hypertension, supraventricular tachycardia, sinus tachycardia, paroxysmal tachycardia, palpitations, etc., were observed in all age groups and both genders. Abnormal ECG findings, elevated C-reactive protein, elevated D-dimer, and troponin associated with the vaccine used in a specific age group or gender or all subjects.
The current analysis shows the total number of cardiovascular adverse events was higher in individuals receiving Pfizer-BioNTech COVID-19 (BNT162b2) vaccine, although the values might not reflect the real situation as it was the first vaccine to get emergency approval from USFDA; hence a large number of doses have been administered till the period of analysis, and other reason could be a shorter interval between the two doses.33
The Case Series Drug Analysis Print published by AstraZeneca for their COVID-19 vaccine as of May 20, 2021, reported a total of 6959 cardiac AEs, among which 4106 events were of palpitations, 1099 were of tachycardia, 129 events of cardiac arrest, 246 events of myocardial infarction, 220 events of atrial fibrillation, 154 events of cardiac flutter, 142 events of angina pectoris, 91 events of arrhythmia, 59 events of sinus tachycardia, 44 events of acute myocardial infarction and 45 events of cardiac failure.34 The data reported from the clinical trials by Moderna in the FDA Briefing Document shows myocardial infarction was reported in 0.03% of cases in the vaccine group.35 Similarly, the data reported by Pfizer-BioNTech COVID-19 Vaccine in the FDA Briefing Document showed one event of cardiac arrest, one event of ventricular arrhythmias, and events of acute myocardial infarction in 0.02% of the patients.36 The Case Series Drug Analysis Print published by Pfizer-BioNTech for their COVID-19 vaccine as of May 28, 2021, reported a total of 2342 cardiac AEs, among which 1098 events were of palpitation, 466 events of tachycardia, 108 events of atrial fibrillation, 94 events of myocardial infarction, 62 events of cardiac arrest, 63 events of cardiac flutter, 32 events of sinus tachycardia, 46 events of angina pectoris, 24 events of cardiac failure, 38 events of arrhythmia and 16 events of acute myocardial infarction.37
The ... data of various cardiac disorders among the general population show that the global population is already prone to various cardiovascular disorders like hypertension, coronary artery diseases, rhythm disorders, etc. Hence, the figures reported as adverse events following various COVID-19 vaccination to the VigiBase cannot be considered purely caused by the vaccines themselves.
Добавлю- далеко не все случаи попали в эти отчеты.
Те данные, что в статье- это только за месяц с начала прививок.
This study included all the adverse events notified concerning all the suspected cardiovascular adverse events reported in VigiBase after administering any of the three COVID-19 vaccines: BNT162b2 Pfizer, 1222 AstraZeneca, and Moderna between December 15, 2020, and January 24, 2021.
There were 103,954 adverse events reported for 30,523 patients from 15th December 2020 to 24th January 2021 (Figure 1). Most of the adverse events (AEs) were reported for three vaccines: BNT162b2 Pfizer, 1222 AstraZeneca, and Moderna COVID-19 vaccines since during the study period, these vaccines were used more commonly. Only one AE was reported from the AG0301-COVID19 vaccine and 32 from SARS-CoV-2 Vaccine (Vero Cell) Inactivated vaccine; none of these AEs were related to the cardiovascular system. A total of 4863 cardiovascular adverse events were reported from the COVID-19 vaccines.
Common adverse events observed with vaccines under study were tachycardia (16.41%), flushing (12.17%). Hypertension (5.82%), hypotension (3.60%) and peripheral coldness (2.41%).
According to the disproportionality analysis based on IC025 values, acute myocardial infarction, cardiac arrest, and circulatory collapse were associated with the vaccine used in the age group > 75 years. Hypertension and severe hypertension like hypertensive emergency and urgency were associated with vaccine use in almost all age groups and genders. Vaccines were also associated with rhythm disorders such as supraventricular tachycardia, sinus tachycardia, paroxysmal tachycardia, palpitations, etc. Peripheral circular failure was also found to be associated with vaccine use. Amongst the investigations and lab tests, abnormal ECG findings, raised C-reactive protein, increase in D-dimer, increase in troponin was found to be associated with the vaccine used in specific age group or gender or all subjects (Table 3).
We explored the global pharmacovigilance database VigiBase for cardiovascular adverse events reported for COVID-19 vaccines in the present study. The majority of the present study’s adverse events were BNT162b2 Pfizer, 1222 AstraZeneca, and Moderna vaccines. The elderly age group was associated with acute myocardial infarction, cardiac arrest, and circulatory collapse. Hypertension, severe hypertension, supraventricular tachycardia, sinus tachycardia, paroxysmal tachycardia, palpitations, etc., were observed in all age groups and both genders. Abnormal ECG findings, elevated C-reactive protein, elevated D-dimer, and troponin associated with the vaccine used in a specific age group or gender or all subjects.
The current analysis shows the total number of cardiovascular adverse events was higher in individuals receiving Pfizer-BioNTech COVID-19 (BNT162b2) vaccine, although the values might not reflect the real situation as it was the first vaccine to get emergency approval from USFDA; hence a large number of doses have been administered till the period of analysis, and other reason could be a shorter interval between the two doses.33
The Case Series Drug Analysis Print published by AstraZeneca for their COVID-19 vaccine as of May 20, 2021, reported a total of 6959 cardiac AEs, among which 4106 events were of palpitations, 1099 were of tachycardia, 129 events of cardiac arrest, 246 events of myocardial infarction, 220 events of atrial fibrillation, 154 events of cardiac flutter, 142 events of angina pectoris, 91 events of arrhythmia, 59 events of sinus tachycardia, 44 events of acute myocardial infarction and 45 events of cardiac failure.34 The data reported from the clinical trials by Moderna in the FDA Briefing Document shows myocardial infarction was reported in 0.03% of cases in the vaccine group.35 Similarly, the data reported by Pfizer-BioNTech COVID-19 Vaccine in the FDA Briefing Document showed one event of cardiac arrest, one event of ventricular arrhythmias, and events of acute myocardial infarction in 0.02% of the patients.36 The Case Series Drug Analysis Print published by Pfizer-BioNTech for their COVID-19 vaccine as of May 28, 2021, reported a total of 2342 cardiac AEs, among which 1098 events were of palpitation, 466 events of tachycardia, 108 events of atrial fibrillation, 94 events of myocardial infarction, 62 events of cardiac arrest, 63 events of cardiac flutter, 32 events of sinus tachycardia, 46 events of angina pectoris, 24 events of cardiac failure, 38 events of arrhythmia and 16 events of acute myocardial infarction.37
The ... data of various cardiac disorders among the general population show that the global population is already prone to various cardiovascular disorders like hypertension, coronary artery diseases, rhythm disorders, etc. Hence, the figures reported as adverse events following various COVID-19 vaccination to the VigiBase cannot be considered purely caused by the vaccines themselves.
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